HSPMdb Accession NoHSPMDB000129
PMID18191466
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of chaperone activity
Compound NameSW03
IUPAC Name3-[(3R)-3-[(3S)-3-{4-[4-(4-bromophenyl)-5-(ethoxycarbonyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]butanamido}-5-methylhexanamido]-3-phenylpropanamido]propanoic acid
SMILESCCOC(=O)C1=C(C)N(CCCC(=O)N[C@@H](CC(C)C)CC(=O)N[C@H](CC(=O)NCCC(O)=O)C2=CC=CC=C2)C(=O)NC1C1=CC=C(Br)C=C1
ClassDihydropyrimidine derivative
EC50 (µM)11
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB000129

SW03

Physicochemical Properties