HSPMdb Accession NoHSPMDB000128
PMID18191466
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of chaperone activity
Compound Name116-10d
IUPAC Namebenzyl 4-{[1,1'-biphenyl]-4-yl}-1-(5-{[(butylcarbamoyl)[4-hydroxy-3-(methoxycarbonyl)phenyl]methyl](hexyl)carbamoyl}pentyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCCCCCCN(C(C(=O)NCCCC)C1=CC=C(O)C(=C1)C(=O)OC)C(=O)CCCCCN1C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)C(C(=O)OCC2=CC=CC=C2)=C1C
ClassDihydropyrimidine derivative
EC50 (µM)9
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB000128

116-10d

Physicochemical Properties