HSPMdb Accession NoHSPMDB000127
PMID18191466
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of chaperone activity
Compound Name116-4d
IUPAC NameN-hydroxy-4-[5-(methoxycarbonyl)-2-oxo-6-(2-phenylethyl)-1,2,3,4-tetrahydropyrimidin-4-yl]-N-oxoanilinium
SMILESCOC(=O)C1=C(CCC2=CC=CC=C2)NC(=O)NC1C1=CC=C(C=C1)[N+](O)=O
ClassDihydropyrimidine derivative
EC50 (µM)8.8
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB000127

116-4d

Physicochemical Properties