HSPMdb Accession NoHSPMDB000126
PMID18191466
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of chaperone activity
Compound Name115-3b
IUPAC Name2-[(2-{5-[(benzyloxy)carbonyl]-1-(3-carboxypropyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-4-yl}phenoxy)sulfonyl]-N-hydroxy-N-oxoanilinium
SMILESCC1=C(C(NC(=O)N1CCCC(O)=O)C1=CC=CC=C1OS(=O)(=O)C1=CC=CC=C1[N+](O)=O)C(=O)OCC1=CC=CC=C1
ClassDihydropyrimidine derivative
EC50 (µM)3.5
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB000126

115-3b

Physicochemical Properties