HSPMdb Accession No | HSPMDB000125 |
PMID | 18191466 |
Target | Hsp70 |
HSP Name | DnaK/DnaJ/GrpE |
Organism | Bacteria |
Localization | Cytosol and membrane |
Enzymatic activity | Inhibition of chaperone activity |
Compound Name | 116-5c |
IUPAC Name | benzyl 4-{[1,1'-biphenyl]-4-yl}-1-(5-{[(butylcarbamoyl)[4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl]methyl](2-phenylethyl)carbamoyl}pentyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
SMILES | CCCCNC(=O)C(N(CCC1=CC=CC=C1)C(=O)CCCCCN1C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)C(C(=O)OCC2=CC=CC=C2)=C1C)C1=CC=C(OCC(=O)OC)C(=C1)C(=O)OC |
Class | Dihydropyrimidine derivative |
EC50 (µM) | 3.2 |
Type of Enzymatic Assay | Refolding assay (luciferase) |