HSPMdb Accession NoHSPMDB000125
PMID18191466
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of chaperone activity
Compound Name116-5c
IUPAC Namebenzyl 4-{[1,1'-biphenyl]-4-yl}-1-(5-{[(butylcarbamoyl)[4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl]methyl](2-phenylethyl)carbamoyl}pentyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCCCCNC(=O)C(N(CCC1=CC=CC=C1)C(=O)CCCCCN1C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)C(C(=O)OCC2=CC=CC=C2)=C1C)C1=CC=C(OCC(=O)OC)C(=C1)C(=O)OC
ClassDihydropyrimidine derivative
EC50 (µM)3.2
Type of Enzymatic AssayRefolding assay (luciferase)

Structure



HSPMDB000125

116-5c

Physicochemical Properties