HSPMdb Accession NoHSPMDB000123
PMID29414793
TargetHsp70
HSP NameHsp72/DnaJ2/BAG2
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameIT2-159
IUPAC NameN-(2,4-difluorophenyl)-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazol-2-amine
SMILESCC1=C(N2C=CC=CC2=N1)C1=CSC(NC2=CC=C(F)C=C2F)=N1
Class2-aminothiazoles derivative
EC50 (µM)5.4
Cellular assayMTT viability assay
Cellular ModelMEF
DiseaseCancer

Structure



HSPMDB000123

IT2-159

Physicochemical Properties