HSPMdb Accession NoHSPMDB000114
PMID29414793
TargetHsp70
HSP NameHsp72/DnaJ2/BAG2
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameIT2-144
IUPAC NameN-(2,5-difluorophenyl)-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazol-2-amine
SMILESCC1=C(N2C=CC=CC2=N1)C1=CSC(NC2=CC(F)=CC=C2F)=N1
Class2-aminothiazoles derivative
EC50 (µM)2.7
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000114

IT2-144

Physicochemical Properties