| HSPMdb Accession No | HSPMDB000112 |
| PMID | 29414793 |
| Target | Hsp70 |
| HSP Name | DnaK/DnaJ/GrpE |
| Organism | Bacteria |
| Localization | Cytosol and membrane |
| Enzymatic activity | Inhibition of ATPase activity (DnaJ stimulated) |
| Compound Name | IT2-21c |
| IUPAC Name | 1-(3,4-dihydroxyphenyl)-2-(4-{[4-(3,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino}-3,5-dimethyl-1H-pyrazol-1-yl)ethan-1-one |
| SMILES | CC1=NN(CC(=O)C2=CC(O)=C(O)C=C2)C(C)=C1NC1=NC(=CS1)C1=CC(O)=C(O)C=C1 |
| Class | IT2-21a derivative |
| % Enzymatic Inhibition/Fold Change | 80% Inhibition at 10 uM |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Type of Enzymatic Assay | ATPase assay |
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