HSPMdb Accession NoHSPMDB000109
PMID29414793
TargetHsp70
HSP NameDnaK/DnaJ/GrpE
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of ATPase activity (protein-protein interaction)
Compound NameIT2-160
IUPAC NameN-(2,6-difluorophenyl)-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazol-2-amine
SMILESCC1=C(N2C=CC=CC2=N1)C1=CSC(NC2=C(F)C=CC=C2F)=N1
Class2-aminothiazoles derivative
EC50 (µM)>25
Site of InteractionNucleotide binding domain (allosteric site)
Type of Enzymatic AssayATPase assay

Structure



HSPMDB000109

IT2-160

Physicochemical Properties