HSPMdb Accession NoHSPMDB000089
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name406
IUPAC Name(E)-N-(1-(3-cyclohexylthioureido)-2-methylpropyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=S)NC2CCCCC2)C(C)C)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition22.6 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB000089

406

Physicochemical Properties