HSPMdb Accession NoHSPMDB000086
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name402
IUPAC Name(E)-N-(1-(3-(4-methoxyphenyl)thioureido)-2-methylpropyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
SMILESCOc1ccc(NC(=S)NC(NC(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition15.4 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB000086

402

Physicochemical Properties