HSPMdb Accession NoHSPMDB000071
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name382
IUPAC Name(E)-N-(2-methyl-1-(3-pyridin-2-ylureido)propyl)-3-(3,4,5-trimethoxyphenyl) acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=O)Nc2ccccn2)C(C)C)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition18.2 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB000071

382

Physicochemical Properties