HSPMdb Accession NoHSPMDB000064
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name374
IUPAC Name(E)-N-(cyclopropyl(3-phenylthioureido)methyl)-3-(3,4,5-trimethoxy-phenyl)acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=S)Nc2ccccc2)C3CC3)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition13.7 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB000064

374

Physicochemical Properties