HSPMdb Accession NoHSPMDB000061
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name371
IUPAC Name(E)-N-(3-methyl-1-(3-pyridin-3-ylthioureido)butyl)-3-(3,4,5-trimethoxyphenyl) acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(CC(C)C)NC(=S)Nc2cccnc2)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition10.5 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB000061

371

Physicochemical Properties