HSPMdb Accession NoHSPMDB000039
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name383
IUPAC Name(E)-N-(2-methyl-1-(3-phenylureido)propyl)-3-(3,4,5-trimethoxy-phenyl) acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=O)Nc2ccccc2)C(C)C)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition4.8 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB000039

383

Physicochemical Properties