HSPMdb Accession NoHSPMDB000037
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name381
IUPAC Name(E)-N-(3,3-dimethyl-1-(3-pyridin-2-ylthioureido)butyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(CC(C)(C)C)NC(=S)Nc2ccccn2)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition25.8 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB000037

381

Physicochemical Properties