HSPMdb Accession No | HSPMDB000034 |
PMID | 27155465 |
Target | Hsp70 |
HSP Name | Hsp70-2 |
Organism | Human |
Localization | Cytosol and cytoskeleton |
Cellular activity | Antiproliferative activity |
Compound Name | 378 |
IUPAC Name | (E)-N-(3-methyl-1-(3-pyridin-2-ylthioureido)butyl)-3-(3,4,5-trimethoxyphenyl)acrylamide |
SMILES | COc1cc(/C=C/C(=O)NC(CC(C)C)NC(=S)Nc2ccccn2)cc(OC)c1OC |
Class | N,N'-disubstituted thiourea derivative |
Site of Interaction | Nucleotide binding domain |
Percentage Cell Growth Inhibition | 24.9 at 10 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | BT474 |
Disease | Cancer |