HSPMdb Accession NoHSPMDB000032
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name375
IUPAC Name(E)-N-(cyclopropyl(3-pyridin-3-ylthioureido)methyl)-3-(3,4,5-trimethoxyphenyl) acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=S)Nc2cccnc2)C3CC3)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition8.6 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB000032

375

Physicochemical Properties