HSPMdb Accession NoHSPMDB000030
PMID27155465
TargetHsp70
HSP NameHsp70-2
OrganismHuman
LocalizationCytosol and cytoskeleton
Cellular activityAntiproliferative activity
Compound Name373
IUPAC Name(E)-N-(2,2-dimethyl-1-(3-pyridin-3-ylthioureido)propyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
SMILESCOc1cc(/C=C/C(=O)NC(NC(=S)Nc2cccnc2)C(C)(C)C)cc(OC)c1OC
ClassN,N'-disubstituted thiourea derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition10.3 at 10 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB000030

373

Physicochemical Properties