HSPMdb Accession No | HSPMDB000006 |
PMID | 19793966 |
Target | Hsp70 |
HSP Name | Hsc70/ DnaJ |
Organism | Human |
Localization | Cytosol and nucleus |
Enzymatic activity | Inhibition of ATPase activity |
Cellular activity | Decreases total tau levels in cells overexpressing human tau protein |
Compound Name | Azure C (AC) |
IUPAC Name | 7-methyliminophenothiazin-10-ium-3-amine;chloride |
SMILES | CN=C1C=CC2=[NH+]C3=C(C=C(C=C3)N)SC2=C1.[Cl-] |
Class | Dihydropyrimidine derivative |
% Enzymatic Inhibition/Fold Change | > 80% |
IC50 (µM) | 11 |
Type of Enzymatic Assay | ATPase assay |
Cellular Model | HeLa |
Disease | Alzheimers disease |