HSPMdb Accession NoHSPMDB000006
PMID19793966
TargetHsp70
HSP NameHsc70/ DnaJ
OrganismHuman
LocalizationCytosol and nucleus
Enzymatic activityInhibition of ATPase activity
Cellular activityDecreases total tau levels in cells overexpressing human tau protein
Compound NameAzure C (AC)
IUPAC Name7-methyliminophenothiazin-10-ium-3-amine;chloride
SMILESCN=C1C=CC2=[NH+]C3=C(C=C(C=C3)N)SC2=C1.[Cl-]
ClassDihydropyrimidine derivative
% Enzymatic Inhibition/Fold Change> 80%
IC50 (µM)11
Type of Enzymatic AssayATPase assay
Cellular ModelHeLa
DiseaseAlzheimers disease

Structure



HSPMDB000006

Azure C (AC)

Physicochemical Properties