HSPMdb Accession NoHSPMDB000003
PMID16982771
TargetHsp70
HSP NameGRP78
OrganismHuman
LocalizationEndoplasmic Reticulum
Enzymatic activityInhibition of ATPase activity
Compound Name(-)-epicatechin-3-gallate (ECG)
IUPAC Name[(2~{R},3~{R})-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2~{H}-chromen-3-yl] 3,4,5-trihydroxybenzoate
SMILESC1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
ClassPolyphenol
% Enzymatic Inhibition/Fold Change64% inhibition at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayATPase assay
DiseaseCancer

Structure



HSPMDB000003

(-)-epicatechin-3-gallate (ECG)

Physicochemical Properties