HSPMdb Accession NoHSPMDB000002
PMID16982771
TargetHsp70
HSP NameGRP78
OrganismHuman
LocalizationEndoplasmic Reticulum
Enzymatic activityInhibition of ATPase activity
Compound Name(-)-epicatechin (EC)
IUPAC Name(2~{R},3~{R})-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2~{H}-chromene-3,5,7-triol
SMILESC1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
ClassPolyphenol
% Enzymatic Inhibition/Fold Change38% inhibition at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayATPase assay
DiseaseCancer

Structure



HSPMDB000002

(-)-epicatechin (EC)

Physicochemical Properties