| HSPMdb Accession No | HSPMDB000001 |
| PMID | 16982771 |
| Target | Hsp70 |
| HSP Name | GRP78 |
| Organism | Human |
| Localization | Endoplasmic Reticulum |
| Enzymatic activity | Inhibition of ATPase activity |
| Cellular activity | Sensitizes human breast cancer cells to etoposide |
| Compound Name | (-)-Epigallocatechin Gallate (EGCG) |
| IUPAC Name | [(2~{R},3~{R})-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2~{H}-chromen-3-yl] 3,4,5-trihydroxybenzoate |
| SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
| Class | Polyphenol |
| % Enzymatic Inhibition/Fold Change | 61% inhibition at 10 uM |
| Kd (µM) | 0.7 |
| Site of Interaction | Nucleotide binding domain |
| Type of Enzymatic Assay | ATPase assay |
| Cellular assay | FACS |
| Cellular Model | MDA-MB-231 and 47D |
| Disease | Cancer |
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