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Compound IDNVIC0069
Compound Structure
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InhibitorPhenytoin
PubChem ID 1775
Drug Bank ID
ChemSpider ID 1710
SMILESC1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Molecular Weight (in g/mol)252.273
TargetNon-selective inhibitor of sodium, sodium/hydrogen transporter and calcium channels
Assay TypeHTS immunolabeling assay
Assay DescriptionNon-linear regression analysis
Assay Source
Cell TypeVero cells
OutcomeSodium channel blockage
IC50 (in nM)51580
EC50 (in nM)
H-bond Acceptor4
H-bond Donor2
No. of Rotatable Bond Count2
XLogP4.71
PSA58.20
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910441/
PubMed ID [Source Literature] 20668647
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