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Compound IDNVIC0018
Compound Structure
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InhibitorKIN1408
PubChem ID 119081414
Drug Bank ID
ChemSpider ID 57251290
SMILESCOC1=CC2=C(C=C1)SC(=N2)NC(C3=CC=C(C=C3)OC(F)F)C4=C(C5=C(C=CC=N5)C=C4)O
Molecular Weight (in g/mol)479.502
TargetActivation of IRF3-dependent innate immune responses
Assay TypePlaque assay
Assay DescriptionTwo-way analysis of variance with Bonferroni posttests
Assay SourceLife Chemicals Inc. and Kineta, Inc.
Cell TypeVero E6 cells
OutcomeDecrease in the number of infectious virus particles
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor7
H-bond Donor2
No. of Rotatable Bond Count7
XLogP5.47
PSA104.74
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
PubMed ID [Source Literature] 26676770
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