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Compound IDNVIC0031
Compound Structure
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InhibitorOSU-03012
PubChem ID 10027278
Drug Bank ID
ChemSpider ID 8202849
SMILESC1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
Molecular Weight (in g/mol)460.46
Target3-phosphinositide-dependent protein kinase 1
Assay TypeLuc reporter assay
Assay DescriptionFit a 4-parameter equation to semilog plots
Assay SourceSelleck Chemicals (Houston, TX, USA)
Cell TypeHEK 293T cells
OutcomeReplication inhibited in NiV-Luc
IC50 (in nM)
EC50 (in nM)400
H-bond Acceptor7
H-bond Donor2
No. of Rotatable Bond Count6
XLogP8.9
PSA72.42
Reference(s)https://www.sciencedirect.com/science/article/pii/S0166354215001126?via%3Dihub
PubMed ID [Source Literature] 25986249
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