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Record - 1 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
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InhibitorGS-5734
PubChem ID 121304016
Drug Bank IDDB14761
ChemSpider ID 58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight (in g/mol)602.585
TargetRNA dependent RNA Polymerase
Assay TypeReporter Virus assay
Assay DescriptionFour-parameter variable slope non-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa or 293?T/17 cells
OutcomeInhibition of transcription in NiV (Rec. M-Luc2AM)
IC50 (in nM)
EC50 (in nM)45
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.1
PSA213.36
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature] 28262699
Curatoranshu@imtech.res.in

                  
Record - 2 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID 121304016
Drug Bank IDDB14761
ChemSpider ID 58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight (in g/mol)602.585
TargetRNA dependent RNA Polymerase
Assay TypeReporter Virus assay
Assay DescriptionFour-parameter variable slope non-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa or 293?T/17 cells
OutcomeInhibition of transcription in NiV (Rec. M-GFP2AM)
IC50 (in nM)
EC50 (in nM)29
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.1
PSA213.36
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature] 28262699
Curatorpriyankapaul008@gmail.com

                  
Record - 3 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID 121304016
Drug Bank IDDB14761
ChemSpider ID 58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight (in g/mol)602.585
TargetRNA dependent RNA Polymerase
Assay TypeVirus titer reduction assay
Assay DescriptionFour-parameter variable slope non-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa cells
OutcomeInhibition of replication in NiV (M-1999)
IC50 (in nM)
EC50 (in nM)47
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.1
PSA213.36
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature] 28262699
Curatorpriyankapaul008@gmail.com

                  
Record - 4 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID 121304016
Drug Bank IDDB14761
ChemSpider ID 58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight (in g/mol)602.585
TargetRNA dependent RNA Polymerase
Assay TypeVirus titer reduction assay / cytopathic effect assay
Assay DescriptionFour-parameter variable slope non-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa or H358 cells
OutcomeInhibition of replication in NiV (B-2004) or Inhibition of virus-induced CPE
IC50 (in nM)
EC50 (in nM)32
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.1
PSA213.36
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature] 28262699
Curatorpriyankapaul008@gmail.com