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Compound IDNVIC0002
Compound Structure
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InhibitorGS-5734
PubChem ID 121304016
Drug Bank IDDB14761
ChemSpider ID 58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight (in g/mol)602.585
TargetRNA dependent RNA Polymerase
Assay TypeReporter Virus assay
Assay DescriptionFour-parameter variable slope non-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa or 293?T/17 cells
OutcomeInhibition of transcription in NiV (Rec. M-GFP2AM)
IC50 (in nM)
EC50 (in nM)29
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.1
PSA213.36
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature] 28262699
Curatorpriyankapaul008@gmail.com