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Record - 1 of 3   [TOP]
Compound IDNVIC0048
Compound Structure
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InhibitorChloroquine
PubChem ID 2719
Drug Bank IDDB00608
ChemSpider ID 2618
SMILESCCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Molecular Weight (in g/mol)319.877
TargetRNA replication
Assay TypeDose-response assay
Assay DescriptionNon-linear regression analysis
Assay SourceSigma
Cell TypeHeLa cells
OutcomeReduce the spread and infection of NiV
IC50 (in nM)620
EC50 (in nM)
H-bond Acceptor3
H-bond Donor1
No. of Rotatable Bond Count8
XLogP4.14
PSA28.16
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888097/
PubMed ID [Source Literature] 19889926
Curatornishisharmacool14@gmail.com

                  
Record - 2 of 3   [TOP]
Compound IDNVIC0048
Compound Structure
DOWNLOAD:
InhibitorChloroquine
PubChem ID 2719
Drug Bank IDDB00608
ChemSpider ID 2618
SMILESCCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Molecular Weight (in g/mol)319.877
TargetCathepsin L
Assay TypeEfficay studies in disease animal model
Assay DescriptionDaily clinical observations
Assay SourceSigma Aldrich, NSW, Australia
Cell TypeFerret model
OutcomePreventing or moderating infection
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor3
H-bond Donor1
No. of Rotatable Bond Count8
XLogP4.14
PSA28.16
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772715/
PubMed ID [Source Literature] 19759137
Curatorkanikatuteja@gmail.com

                  
Record - 3 of 3   [TOP]
Compound IDNVIC0048
Compound Structure
DOWNLOAD:
InhibitorChloroquine
PubChem ID 2719
Drug Bank IDDB00608
ChemSpider ID 2618
SMILESCCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Molecular Weight (in g/mol)319.877
TargetF protein
Assay TypeHigh throughput screening assay
Assay DescriptionMulticycle replication assay
Assay Source
Cell TypeVero cell
OutcomeReduced the virus titer
IC50 (in nM)2000
EC50 (in nM)
H-bond Acceptor3
H-bond Donor1
No. of Rotatable Bond Count8
XLogP4.14
PSA28.16
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
PubMed ID [Source Literature] 19264786
Curatorkanikatuteja@gmail.com