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Compound IDNVIC0010.1
Compound Structure
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Inhibitor4-oxo-1,4-Dihydroquinoline-3,5-dicarboxylic Acid
PubChem ID 91619677
Drug Bank ID
ChemSpider ID 62941102
SMILESC1=CC(=C2C(=C1)NC=C(C2=O)C(=O)O)C(=O)O
Molecular Weight (in g/mol)233.179 g/mol for both
Targetprotein cavity in the NiV-F protein
Assay TypeNiV F protein-based fusion assay
Assay Descriptionsize of the syncytia (average number of nuclei in syncytia) was determined in the microscope
Assay Source
Cell TypeVero cells
OutcomeCell?Cell Fusion Inhibiting Activity Determined in NiV-G/F
IC50 (in nM)
EC50 (in nM)8000
H-bond Acceptor6
H-bond Donor3
No. of Rotatable Bond Count2
XLogP1.46
PSA103.70
Reference(s)https://pubs.acs.org/doi/full/10.1021/jm900411s
PubMed ID [Source Literature] 19499921
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