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Compound IDNVIC0001
Compound Structure
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InhibitorGS-441524
PubChem ID N.A
Drug Bank ID
ChemSpider ID 28499861
SMILESC1cc(n2c1c(ncn2)N)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N
Molecular Weight (in g/mol)531.202 Da
TargetRNA dependent RNA Polymerase
Assay TypeFIPV Replication assay
Assay DescriptionqRT-PCR
Assay SourceGS-441524 - provided by Gilead Sciences, Inc
Cell TypeCrandell-Rees Feline Kidney (CRFK) cells
Outcomesuppression of viral RNA expression
IC50 (in nM)
EC50 (in nM)780
H-bond Acceptor10
H-bond Donor3
No. of Rotatable Bond Count8
XLogP-6.1
PSA330.26
Reference(s)https://www.sciencedirect.com/science/article/pii/S0378113518301603?via%3Dihub
PubMed ID [Source Literature] 29778200
Curatoranshu@imtech.res.in