SMEpred
MultiModGen: siRNA Multiple Modification Generating algorithm

MultiModGen allows user to custom create different chemical modifications on multiple locations in input siRNA sequences i.e. it will create user defined nucleotide modification at given positions in input siRNA sequence. After getting custom modifications in siRNA sequences user can use SMEpred webserver or more specifically  siMEPred to predict efficiency of the chemically modified siRNA with download option available in the page. For more information about the chemical modifications and symbols, we have provided the dropdown option on the right side of page or please click FAQs-Help.


::MultiModGen::
        Enter a siRNA sequence (one sequence in one line) below:  

        
          

         Or load it from disk   


        Chemical Modification:                                       

        
        Or load it from disk   


        Modification positions :                          

        
        Or load it from disk   

                         


One letter Code Chemical Modification name list
B 2'-N-Adamant-1-yl-Methylcarbonyl-2'-Amino-Locked Nucleic Acid
D 2'-Aminoethoxymethyl Nucleic Acid
E 2'-Aminoethyl Nucleic Acid
F 2'-Fluoro Nucleic Acid
H 4'-C-Hydroxymethyl Deoxyribonucleic acid
I Altritol Nucleic Acid
J 2'-Aminopropyl Nucleic Acid
K 2'-aminopropoxymethyl Nucleic Acid
L Locked Nucleic Acid
M 2'-Deoxy-2'-N,4'-C-Ethylene-Locked Nucleic Acid
N Alfa-L-Locked Nucleic Acid
O 2'-Cyanoethyl Nucleic Acid
P 2',4'-Carbocyclic-Ethylene-bridged Nucleic Acid-Locked Nucleic Acid
Q 2',4'-Carbocyclic-Locked Nucleic Acid-Locked Nucleic Acid
R 2'-Guanidinoethyl Nucleic Acid
S Hexitol Nucleic Acid
V Oxetane-Locked Nucleic Acid
W 2'-N-Pyren-1-yl Methyl-2'-Amino-Locked Nucleic Acid
X Unlocked Nucleic Acid
Y 2'-O-Methyl Nucleic Acid
Z 2'-Deoxy Nucleic Acid
b 2'-Deoxy-2'-Fluoro Nucleic Acid
d 2'-O-Benzyl Nucleic Acid
e 2'-O-Guanidinopropyl Nucleic Acid
g Boranophosphate Nucleic Acid
h Dihydrouridine Nucleic Acid
m Hypoxanthine Nucleic Acid
n Peptide Nucleic Acids
q Phosphorothioate Nucleic Acid
r Tricyclodeoxyribo Nucleic Acid