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Compound IDNVIC0007
Compound Structure
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InhibitorCHEMBL551897
PubChem ID   44191117
Drug Bank ID
ChemSpider ID24618777
SMILESCCOC(=O)N1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)NCC4=C(C=C(C=C4)Cl)Cl)C5CC5)F
Molecular Weight561.435 g/mol
TargetNiV F protein
Assay TypeNiV F protein-based fusion assay
Assay DescriptionSize of the syncytia (average number of nuclei in syncytia) was determined in the microscope
Assay SourceHttps://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
Cell TypeVero cells
OutcomeInhibit NiV-induced virus-cell and cell?cell fusion
IC50 (in nM)
EC50 (in nM)3000
H-bond Acceptor11
H-bond Donor1
No. of Rotatable Bond Count9
XLogP4.86
PSA82.19
Reference(s)Https://pubs.acs.org/doi/full/10.1021/jm900411s
PubMed ID [Source Literature]19499921
CuratorAnshu@imtech.res.in