logo
                  
Record - 1 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeREPORTER ASSAYS
Assay DescriptionDose-response curve analysis
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeInhibition of transcription in NiV-Luc2AM
IC50 (in nM)
EC50 (in nM)1120
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pubmed/28629988
PubMed ID [Source Literature]28629988
CuratorAnshu@imtech.res.in

                  
Record - 2 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeCytopathic effect assay(CPE)
Assay DescriptionHigh-throughput screening
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeChain termination, halt in replication
IC50 (in nM)
EC50 (in nM)2630
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorKanikatuteja@gmail.com

                  
Record - 3 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeCytopathic effect assay(CPE)
Assay DescriptionHigh-throughput screening
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeHeLa
OutcomeChain termination, halt in replication
IC50 (in nM)
EC50 (in nM)13550
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorKanikatuteja@gmail.com

                  
Record - 4 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeWT virus titer reduction
Assay DescriptionVisually inquired for CPE
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeChain termination, halt in replication
IC50 (in nM)
EC50 (in nM)1530
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorKanikatuteja@gmail.com

                  
Record - 5 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeREPORTER ASSAYS
Assay DescriptionDose-response curve analysis
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeHeLa
OutcomeInhibition of transcription in NiV-Luc2AM
IC50 (in nM)
EC50 (in nM)5680
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorPriyankapaul008@gmail.com

                  
Record - 6 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeReporter assay
Assay DescriptionDose-response curve analysis
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeInhibition of transcription in NiV-GFP2AM
IC50 (in nM)
EC50 (in nM)1640
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorPriyankapaul008@gmail.com

                  
Record - 7 of 7   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID   457388
Drug Bank ID
ChemSpider ID402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeVirus titer reduction
Assay DescriptionVisually assayed for CPE
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeHeLa
OutcomeReplication inhibition in wild type Niv-M
IC50 (in nM)
EC50 (in nM)4000
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature]28629988
CuratorPriyankapaul008@gmail.com