logo
                  
Record - 1 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID   121304016
Drug Bank ID
ChemSpider ID58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Molecular Weight602.585 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeReporter assay
Assay DescriptionNon-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa
OutcomeInhibition of transcription in NiV (Rec. M-Luc2AM)
IC50 (in nM)
EC50 (in nM)45
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.10
PSA213.36
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature]28262699
CuratorAnshu@imtech.res.in

                  
Record - 2 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID   121304016
Drug Bank ID
ChemSpider ID58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C5
Molecular Weight602.585 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeReporter assay
Assay DescriptionNon-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa
OutcomeInhibition of transcription in NiV (Rec. M-GFP2AM)
IC50 (in nM)
EC50 (in nM)29
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.10
PSA213.36
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature]28262699
CuratorPriyankapaul008@gmail.com

                  
Record - 3 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID   121304016
Drug Bank ID
ChemSpider ID58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C6
Molecular Weight602.585 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeVirus titer reduction assay (VTR)
Assay DescriptionNon-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeVero cells
OutcomeInhibition of replication in NiV (M-1999)
IC50 (in nM)
EC50 (in nM)47
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.10
PSA213.36
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature]28262699
CuratorPriyankapaul008@gmail.com

                  
Record - 4 of 4   [TOP]
Compound IDNVIC0002
Compound Structure
DOWNLOAD:
InhibitorGS-5734
PubChem ID   121304016
Drug Bank ID
ChemSpider ID58827832
SMILESCCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C7
Molecular Weight602.585 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeVirus titer reduction assay (VTR)/ cytopathic effect assay(CPE)
Assay DescriptionNon-linear regression fitting
Assay SourceGS-5734 were synthesized at Gilead Sciences, Inc.
Cell TypeVero cells
OutcomeInhibition of replication in NiV (B-2004)
IC50 (in nM)
EC50 (in nM)32
H-bond Acceptor10
H-bond Donor4
No. of Rotatable Bond Count14
XLogP2.10
PSA213.36
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
PubMed ID [Source Literature]28262699
CuratorPriyankapaul008@gmail.com